The Hawai‘i Department of Health (DOH) has unveiled comprehensive guidance to combat respiratory viruses, notably COVID-19. This guidance harmonizes with CDC’s recent updates, focusing on preventative measures to curb virus transmission in the community and stressing the importance of early detection for high-risk individuals. With respiratory illnesses prevalent year-round in Hawai‘i, these insights are pivotal for navigating COVID-19, flu, and RSV. Emphasizing vaccinations, home care when ill, masking, and hygiene, DOH’s initiative is a crucial step towards safeguarding public health amidst ongoing threats.